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Children 8 years of age who consumed 20 to antibiotic iv therapy pangamil 1000 mg amex 40 µg/day of iodine were in negative iodine balance (­23 to antibiotic dosage for uti pangamil 1000mg cheap ­26 µg/day) (Malvaux et al. The prevalence of goiter was estimated in European boys and girls aged 6 to 15 years (Delange et al. Because iodine deficiency is rare in the United States, data from Europe are used to relate goiter, as determined by ultrasound, to urinary iodine excretion. As urinary iodine excretion increases, the goiter prevalence decreases and eventually changes only slightly (Figure 8-1). As described earlier, the daily iodine intake can be estimated from the urinary iodine concentration as follows: 1. Therefore, for a 10-year-old child weighing 40 kg, the urinary iodine concentration of 100 µg/L approximates a daily iodine intake of 125 µg (1. Malvaux and coworkers (1969) conducted a balance study on 16 boys and girls (aged 9 to 13 years) in Belgium. This finding would suggest a minimum average requirement of approximately 55 µg/day (31 + 24). The iodine requirement has not been determined based on energy expenditure; however, the thyroid hormones, which contain iodine, are involved with metabolic rate. Malvaux and colleagues (1969) reported that the average iodine balance of 10 children (aged 14 to 16 years) was ­24 µg/day when they consumed an average 34 µg/day of iodine, which would give 58 µg/day as an average requirement. No other data are available for estimating an average requirement for this age group. Turnover studies have been conducted in euthyroid adults (Fisher and Oddie, 1969a, 1969b). In one of these studies, the average accumulation of radioiodine by the thyroid gland for 18 men and women aged 21 to 48 years was 96. The accumulation of radioidine by the thyroid gland correlated well with urinary radioidine excretion. DeGroot (1966) measured iodine turnover in four normal subjects by three methods: Copyright © National Academy of Sciences. There is no evidence to suggest that the average iodine requirement is altered with aging, or to have differences based on gender in adults. A study by Vought and London (1967) demonstrated that the obligatory amount of iodine excreted was 57 µg/day. Despite the methodologic limitations of balance studies, when 100 µg/day of iodine was provided to 13 subjects, an average slight positive balance (13 µg) was observed (Harrison, 1968). In a study of five pregnant and four nonpregnant women, balance was calculated at about 160 µg/day (Dworkin et al. Given this higher estimate in women, adjusting for smaller body weight in women was not justified. Part of this variation is due to the complexity of the experimental design and calculations used to estimate turnover. The daily accumulation of iodine by the newborn can be used to estimate the daily fetal iodine uptake. It is estimated that the average iodine content of the newborn thyroid gland is 50 to 100 µg with close to 100 percent being turned over daily (Delange, 1989; Delange and Ermans, 1991). Iodine balance studies by Delange and coworkers (1984) showed that the average iodine retention of full-term infants was 6. With an average fetal weight of 3 kg, the mean retention of a fully developed fetus would be approximately 22 µg/ day. A study demonstrated that pregnant women were at balance when consuming approximately 160 µg/day (Dworkin et al. Studies have measured thyroid volume by ultrasound and correlated it with urinary iodine excretion and the effects of iodine supplementation during pregnancy (Berghout and Wiersinga, 1998). Pregnant women in an iodine-deficient area of Italy were given iodized salt estimated Copyright © National Academy of Sciences.

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Adding this layer of management will provide the state with additional costs savings on many of its large scale publicly-funded construction projects antibiotics dosage cheap pangamil 500mg without a prescription. The Governor has committed $1 the Governor applied the same bottom-up Institution antibiotic strep throat generic pangamil 300mg otc, McKinsey & Company, and the future of the region. Solar power provider SolarCity Innovation Hub at RiverBend with a ten-year, $5 billion investment that will create approximately 3, 000 53 will anchor the Buffalo High Tech Manufacturing permanent jobs in Buffalo and 2, 000 jobs elsewhere in innovation the state. Overall, the Buffalo Billion will generate a total investment of over $8 billion and create approximately 14, 000 direct and indirect jobs. Billion model, To replicate the Revitalization projects in the city of Buffalo and success of the Buffalo Governor launched the Upstate the the state is investing more than $108 million in Overall, the Buffalo Billion will generate a total investment of over $8 billion and create approximately 14, 000 direct and indirect jobs. Lakes, and Southern Tier ­ $500 million each over five economic opportunity within 54 a $1. Establishing recognized as an effective way for states to coordinate prominent economist Michael Porter, clusters allow academia, and government, driving regions to coordinate existing resources in industry, their economic development efforts. In 2015, the New After decades of false starts and promises, York State Gaming Commission unanimously approved Schenectady, and Seneca Counties. Ten percent will provide local government assistance to each county in the three upstate casino-eligible regions, and the final industry, and government leaders to plan the future of 56 Economic Development Council competition to develop their region. In total, the average investment in each of these regions will be nearly $145 million. Eligible projects will include those workforce will want to live, work, and raise a family. In 2015, events million visitors, including more than 908, 000 for the Great New York State Fair alone. In 2017 and 2018, the facilities, a large Expo Center, and new festival grounds historic Erie Canal. To shine a another round of special events including winter and Governor Cuomo will host his first annual Catskill and local officials, 62 summer events in the Adirondacks, fishing tournaments Proposal: Adirondack and New Challenges Challenge this summer. Modeled after the successful state tourism annual Adirondack Challenge, the Governor will invite industry representatives, and outdoor enthusiasts to engage in a day of world-class outdoor activities, while showcasing biking. This Catskills" tourism website, an online resource that locals to enjoy while traveling by motorcycle, car, bike, boat, or foot. The project will feature a 6, 000-square-foot million to transform Minnewaska Preserve State Park, on New York will also further its long standing visitor center, improved parking, better parking, and space for exhibits and education services. Last year, farmers in New York State set an these investments are already paying dramatic more each day than Greece does. As part of this effort, the state is investing $20 million to protect farmland in the Hudson Valley-the first-ever regional farmland protection initiative of its kind. The state is also businesses throughout the Southern Tier to increase production, spur economic development, and introduce environmental stewardship best practices. In 2015, the state adopted a recommendation of the Task Force and streamlined registration environmental protections. New York State now ranks in apple production, and is home to three of the 20 top- New York has emerged as a national leader in business friendly reforms that have resulted in businesses, and he has committed $9 million to promote producing breweries in the country. Since 2010, the number of farm wineries in New York has increased by remarkable growth. He created the One Stop Shop, which third in the nation in wine and grape production, second over 60 percent and the number of microbreweries has increased by 233 percent. Since Governor Cuomo took office, farm-based beverage licenses have more than 67 doubled and the new Farm Brewery Law has already resulted in 106 new licensees. In 2015 alone, the State Liquor Authority issued 141 new manufacturing 25 winery licenses, and 73 brewers. Just two years later, Todd 68 highlight and encourage the purchase of New York-made foods and beverages. To encourage the growth of start-up craft beverage producers, the Governor proposes to expand eligibility for this tax credit beyond breweries to cideries that distilleries that produce less than 500, 000 gallons and grow their companies in New York. These proposals will provide $2 million in breweries, distilleries, cideries, and wineries from lowering costs for hundreds of craft producers and million in these taxes last year and the craft industry accounts for $10 million of the total.

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Other Adverse Effects Other adverse effects observed after high chromium intakes include rhabdomyolysis (Martin and Fuller antibiotics for sinus infection in toddlers purchase 500 mg pangamil with amex, 1998) antibiotics and iud discount pangamil 300mg amex. Rhabdomyolysis is characterized by skeletal muscle injury and release of muscle cell contents into the plasma. Reports of chromium-induced rhabdomyolysis failed to account for other potential etiologic factors including strenuous exercise, weight lifting, trauma, seizure, sepsis, and alcohol and drug abuse. Because of the current widespread use of chromium supplements, more research is needed to assess the safety of high-dose chromium intake from supplements. Data from randomized, doubleblind, controlled clinical trials and surveillance studies would be most useful for assessing the safety of chromium intake in humans. Intake Assessment National survey data are not available on the intake of chromium at various percentiles. According to data from the Third National Health and Nutrition Examination Survey, the average supplemental intake of chromium at the ninety-fifth percentile was 100 µg/day for men and 127 µg/day for women (Appendix Table C-14). Risk Characterization No adverse effects have been convincingly associated with excess intake of chromium from food or supplements, but this does not mean that there is no potential for adverse effects resulting from high intakes. Since data on the adverse effects of chromium intake are limited, caution may be warranted. Sexual maturation and fertility of male and female mice exposed prenatally and postnatally to trivalent and hexavalent chromium compounds. Chromium intake, absorption and excretion of subjects consuming self-selected diets. Effect of exercise (running) on serum glucose, insulin, glucagon, and chromium excretion. Effects of chromium supplementation on urinary Cr excretion of human subjects and correlation of Cr excretion with selected clinical parameters. Strenuous running: Acute effects on chromium, copper, zinc, and selected clinical variables in urine and serum of male runners. Exercise effects on chromium excretion of trained and untrained men consuming a constant diet. Supplemental-chromium effects on glucose, insulin, glucagon, and urinary chromium losses in subjects consuming controlled low-chromium diets. Breast milk chromium and its association with chromium intake, chromium excretion, and serum chromium. Dietary intake of calcium, chromium, copper, iron, magnesium, manganese, and zinc: Duplicate plate values corrected using derived nutrient intake. Elevated intakes of supplemental chromium improve glucose and insulin variables in individuals with type 2 diabetes. Effect of long-term ingestion of chromium compounds on aggression, sex behavior and fertility in adult male rat. Determination and levels of chromium in French wine and grapes by graphite furnace atomic absorption spectrometry. Chromium picolinate supplementation and resistive training by older men: Effects on ironstatus and hematologic indexes. Isolation and characterization of a biologically active chromium oligopeptide from bovine liver. Effects of over-the-counter drugs on 51chromium retention and urinary excretion in rats. Metabolism of chromium-51 in human subjects-Normal, elderly, and diabetic subjects. Effects of amino acids on the absorption of trivalent chromium and its retention by regions of the rat small intestine. Long-term exposure of male and female mice to trivalent and hexavalent chromium compounds: Effect on fertility. Breastfeeding, Nutrition, Infection and Infant Growth in Developed and Emerging Countries. Testicular toxicity following short-term exposure to tri- and hexavalent chromium: An experimental study in the rat.

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Reading well-crafted literature provides a model that illustrates the characteristics of good writing antibiotic resistant uti discount pangamil 500 mg fast delivery. Reading also provides a vehicle for learning about the different purposes and forms of writing antibiotic resistance timeline generic pangamil 1000 mg on-line. As students read an autobiography, for instance, they are likely to notice how the author presents himself. An astute reader may also notice the author uses his life story as a means for sharing lessons learned about living well or poorly. While students clearly acquire some knowledge about writing through reading, how much they learn is unknown. Teachers can enhance this process by engaging students in a discussion of what an author is trying to achieve, and then asking them to apply the same procedures to their own writing. Then ask students to try to use words to evoke a similar feeling in their own writing. For example, when introducing students to mystery writing, a good starting point is to examine several mysteries to identify common features, such as placing the story in a particular place and time or the use of cues and false leads. Students can then be asked to generate a mystery of their own, using the model to guide their efforts. While such discourse knowledge is important, it has little impact if the writer knows little about the topic of their composition. If this is the case, students can acquire knowledge from written or electronic sources, interviews, surveys, or observations. One effective approach for obtaining information for writing is inquiry (#6: Graham & Perin, 2007a). To illustrate, a teacher may ask students to write a paper where conflict is an important element in the story. Next, each student develops a plan for collecting and analyzing data on conflict. Too quickly many of them come to view school writing as a chore or something to be avoided altogether. How can we create an environment in which developing writers not only flourish, but also learn to enjoy writing? For example, it is more motivating to write a letter to a real person than an imaginary one. And students are more likely to enjoy writing if the classroom environment is a supportive and pleasant place (#8: Graham & Perin, 2007a). For instance, a good rule to follow is when a student shares a composition, the first feedback provided by students and teachers alike are comments about what is liked best about the piece. This is most effective when the process of working together is structured so each person knows what they are expected to do. Especially productive collaborations occur when students help each other as they plan, draft, revise, edit, and/or publish their work (#9: Graham & Perin, 2007a, 2007b). To illustrate with revising, one student might read a completed 4 composition to a peer, who then tells the writer several things he liked about it. Next, the reader reads the paper to identify places that are unclear or where additional information is needed. The reader shares this information with the writer by asking, "What did you mean here? Your students are also likely to be more motivated to write if you are enthusiastic about writing (#10: Graham & Perin, 2007b). Set high, but realistic, expectations for your students (#11: Graham & Perin, 2007b), and help them develop an "I can do" attitude. When they need help, provide just enough support so they can make progress in carrying out the writing task, but encourage them to do as much as they can on their own (#12: Graham & Perin, 2007b). This can be fostered by encouraging them to construct a personal plan for accomplishing the writing task, to work at their own pace (when possible), and to decide which feedback from peers and the teacher is most pertinent for revising a paper. Much of this thinking centers on the basic processes of writing: planning, drafting, revising, and editing (Graham, 2006). One thing exceptional writing teachers do is set up a predictable writing routine where students are expected to plan, draft, revise, edit, and share what they write (#13: Graham & Perin, 2007a, 2007b). In essence, they treat writing as a process and expect students to engage in the same processes as skilled writers. One means of support involves the use of think sheets or graphic organizers that structure what students do as they plan, draft, revise, or edit (#14: Graham & Perin, 2007a; Rogers & Graham, 2008).

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In many instances over the past 15 years antibiotic resistance finder discount pangamil 300mg line, Guard and Reservists were given inaccurate information about their eligibility for educational entitlements best antibiotic for sinus infection clindamycin cheap pangamil 1000mg free shipping. In addition to the federal Veterans Administration, there is a veterans department in almost every state. The book became a national bestseller and received strong endorsements from the media, including "Dear Abby. Into the void come two of the coauthors of the Viet Vet Survival Guide, along with approximately 30 other experts on issues regarding servicemembers and veterans. Unlike the original, however, this one covers not just veterans but also servicemembers. TheAmericanVeteransandServicemembersSurvivalGuide 29 Also, instead of being exclusively for veterans of one era, the new book is for veterans (and, as stated, for servicemembers) of all periods. The book gives particular emphasis to servicemembers and veterans of Iraq and Afghanistan, while providing adequate information for vets of all other eras. The American Servicemembers and Veterans Survival Guide describes in depth the problems of the vet and servicemember (and his or her family), the benefits and services available to him or her (and family) and the veterans and servicemembers issues that will be decided in the next several years. Most important, it helps the veteran and servicemember understand how various agencies work not just in theory but in practice and how he or she can cut through the bureaucracy and confusion and get the benefits and services to which he or she is entitled. Topics include, among others, frequent call-ups from the Guard and Reserve, getting out of the military, the Department of Veterans Affairs, disability compensation, pensions, medical care, educational benefits, housing benefits, claims and appeals, discharge upgrading, the criminal justice system, employment, reemployment rights, benefits for family members, the special problems of women servicemembers and veterans and domestic relations issues. It allows for updating as needed, not just when a new edition might come out in a matter of years. Similarly, we can begin publishing this book not when a whole, long manuscript is in final form, but rather as soon as one or several chapters are ready. It also deals with programs administered by other federal agencies and the states. We suggest that you look through the table of contents and then carefully read each chapter that you know applies to you or that you think may apply to you. For one thing, you may very well come across a benefit program or other information that-surprise-can help you. For another thing, you may find something that you will want to pass along to a friend who is a veteran. Now we want to pass along some information, most of it very important, that applies to most or all the chapters in this book. These may have to do with how long you served, what kind of discharge you received, and whether any disability you have is connected to your military service. Most of the time, but not always, if you are eligible, all you have to do to become entitled is to submit a form and wait for approval. So you may have to appeal an adverse 34 BasicSurvivalSkills decision or at least provide more information. Specific chapters in this part of the book explain how to qualify for specific benefits. You are in almost all cases not eligible if you have a dishonorable discharge or a bad-conduct discharge issued by a general courtmartial. TypeofService To be eligible for federal and state veterans programs, you must in almost all cases have had "active service. This does not mean the veteran must have engaged in combat or served in a combat zone (such as Iraq). The wars in Iraq and Afghanistan have been designated as part of the period beginning on August 2, 1990, during the first Gulf War. So you qualify if you served anywhere-in Iraq, Germany, or Kansas-anytime on or after August 2, 1990. Another alternative is to look in the "United States Government" listings near the front of your phone book, under "Veterans Affairs. A local phone book is also helpful in finding other government agencies, veterans organizations and most anybody else. Click on "Find a Facility, " then click on the down arrow and then on "Benefits Office. If your interest is not benefits but medical care, select not "Benefits Office" but "Medical Facilities. These centers are mostly for counseling on issues of psychological readjustment to civilian life.

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Ethical considerations in deep brain stimulation for the treatment of addiction and overeating associated with obesity infection going around safe 1000 mg pangamil. Antipsychotic augmentation with modafinil or armodafinil for negative symptoms of schizophrenia: Systematic review and meta-analysis of randomized controlled trials antimicrobial iphone case cheap pangamil 1000 mg visa. Smart drugs for cognitive enhancement: Ethical and pragmatic considerations in the era of cosmetic neurology. Anticipate and Communicate: Ethical Management of Incidental and Secondary Findings in the Clinical, Research, and Direct-toConsumer Contexts. Pharmacological cognitive enhancement-How neuroscientific research could advance ethical debate. Prevalence of Autism Spectrum Disorder among children aged 8 years-Autism and Developmental Disabilities Monitoring Network, 11 sites, United States, 2010. Propranolol and the prevention of post-traumatic stress disorder: Is it wrong to erase the "sting" of bad memories? Illicit use of specific prescription stimulants among college students: Prevalence, motives, and routes of administration. Modafinil and methylphenidate for neuroenhancement in healthy individuals: A systematic review. Risk of serious cardiovascular problems with medications for attention-deficit hyperactivity disorder. Neuroenhancement in young people: Proposal for research, policy, and clinical management. Methylphenidate-induced dendritic spine formation and FosB expression in nucleus accumbens. Neurobehavioral adaptations to methylphenidate: the issue of early adolescent exposure. Boosting brain functions: Improving executive functions with behavioral training, neurostimulation, and neurofeedback. Botox for the brain: enhancement of cognition, mood and pro-social behavior and blunting of unwanted memories. Serotonin selectively influences moral judgment and behavior through effects on harm aversion. See the Kavli Foundation, the Gatsby Foundation, and the Society for Neuroscience. Reach and grasp by people with tetraplegia using a neurally controlled robotic arm. Transcranial magnetic stimulation, deep brain stimulation and personal identity: Ethical questions, and neuroethical approaches for medical practice. Ethics of the electrified mind: Defining issues and perspectives on the principled use of brain stimulation in medical research and clinical care. Changes in capacity to consent over time in patients involved in psychiatric research. Cognitive side-effects of electroconvulsive therapy in elderly depressed patients. Speaking of research advance directives: Planning for future research participation. The association of specific neuropsychological deficits with capacity to consent to research or treatment. National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research (National Commission). Authenticity in community: Theory and practice of an inclusive anthropology in care for persons with intellectual disabilities. Advance directives for non-therapeutic dementia research: Some ethical and policy considerations. Ethics in Psychiatric Research: A Resource Manual for Human Subjects Protection (pp. For example, "subjects enrolled by surrogate consent were older and had more severe strokes than persons enrolled by their own consent. The limitations of "vulnerability" as a protection for human research participants.

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However antibiotic resistance livestock humans order pangamil 1000mg with amex, these tests are more invasive than dark adaptation and there are not as many data relating these functional tests to treatment for sinus infection home remedies purchase 300 mg pangamil with amex dietary vitamin A levels. There is literature relating dark adaptation test results to dietary levels of vitamin A under controlled experimental conditions (Table 4-4). Under controlled feeding conditions, dark adaptation, objectively measured by dark adaptometry, is one of the most sensitive indicators of a change in vitamin A deficiency status (Figure 4-3). Epidemiological evidence suggests that host resistance to infection is impaired at lesser stages of vitamin A deficiency, prior to clinical onset of night blindness (Arroyave et al. Moreover, laboratory animals fed a vitamin A-deficient diet maintain ocular levels of vitamin A despite a significant reduction in hepatic vitamin A levels (Bankson et al. Nevertheless, this approach can be used to estimate the average requirement for vitamin A but without assurance of adequate tissue levels to meet nonvisual needs for vitamin A. Pupillary Response Test Another test of ability to dark adapt, one that avoids reliance on psychophysical responses, is the pupillary response test that measures the threshold of light at which a pupillary reflex (contraction) first occurs under dark-adapted conditions (Stewart and Young, 1989). The retina of one eye is briefly exposed to incremental pulses Copyright © National Academy of Sciences. A high scotopic (vision in dim light) threshold indicates low retinal sensitivity, a pathophysiological response to vitamin A deficiency. An early report of pupillary nonresponse to candlelight among night blind Confederate soldiers in the Civil War (Hicks, 1867) led to the development and validation of instrumentation for this test as a reliable, functional measure of vitamin A deficiency in Indonesian (Congdon et al. However, data do not currently exist relating pupillary threshold sensitivity as determined by this test to usual vitamin A intakes, and so measures of pupillary response cannot be used at the present to establish dietary vitamin A requirements. Plasma Retinol Concentration the concentration of plasma retinol is under tight homeostatic control in individuals and therefore is insensitive to liver vitamin A stores. When liver vitamin A reserves fall below a critical concentration, thought to be approximately 20 µg/g of liver (Olson, 1987), plasma retinol concentration declines. When dietary vitamin A is provided to vitamin A-deficient children, plasma retinol concentration increases rapidly, even before liver stores are restored (Devadas et al. Thus, a low concentration of plasma retinol may indicate inadequacy of vitamin A status, although median or mean concentrations for plasma retinol may not be well correlated with valid indicators of vitamin A status. In malnourished populations, often 25 percent or more individuals exhibit a plasma retinol concentration below 0. The presence of one or more of these factors could lead to an overestimation of the prevalence of vitamin Copyright © National Academy of Sciences. According to an analysis of the Third National Health and Nutrition Examination Survey, individuals in the highest quartile for vitamin A intake had only slightly higher serum retinol concentrations than those in the lowest quartile for vitamin A intake (Appendix Tables H-1 and H-2). Excluding pregnant women, less than 5 percent of adults had a serum retinol concentration less than 1. Because of the relatively insensitive relationship be- Copyright © National Academy of Sciences. Total Liver Reserves by Isotope Dilution Body stores of vitamin A can be estimated directly by liver biopsy, but this is not an appropriate indicator of status, except at autopsy, for a population. Vitamin A stores can also be estimated by an indirect approach using an isotope dilution technique. This technique involves administering an oral dose of stable-isotopically labeled vitamin A and, after a period of equilibration, drawing blood for measurement of the isotopic ratio in plasma. Liver reserves of vitamin A can be correlated with known dietary intake levels of vitamin A. Relative Dose Response and Modified Relative Dose Response In healthy individuals, approximately 90 percent of vitamin A in the body is stored in the liver and this percentage decreases to 50 percent or less in severely deficient individuals (Olson, 1987). Hepatic vitamin A stores can thus be interpreted to reflect nutrient adequacy to meet total body needs, barring factors that impede Copyright © National Academy of Sciences. The test was subsequently validated against measured liver retinol stores in humans (Amedee-Manesme et al. For the test, a blood sample is drawn before retinol administration (zero time), and then a small dose of vitamin A is administered; a second blood sample is taken after an interval, generally 5 hours. The concentration of retinol in each sample is determined and the difference (response) in plasma retinol concentration (5 hours minus zero hours) is calculated and expressed as a percentage of the 5-hour concentration. Although various cutoff levels have been used, a plasma retinol response greater than or equal to 20 percent is generally considered to indicate that liver vitamin A is inadequate (Tanumihardjo, 1993). An alternative approach involves transferring cell specimens from the filter paper to a glass slide before staining and examination (Carlier et al.

References:

  • https://www.ema.europa.eu/en/documents/scientific-discussion/avastin-epar-scientific-discussion_en.pdf
  • https://jamanetwork.com/journals/jamainternalmedicine/articlepdf/574437/archinte_121_5_002.pdf
  • https://cstn.files.wordpress.com/2009/10/qualitative-research.pdf
  • https://www.cartercenter.org/resources/pdfs/health/ephti/library/lecture_notes/health_science_students/ln_phys_diagnosis_final.pdf
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